Dependent

Effect

df

SS

MS

F

Probability

Ln(Cmax)

Sequence

1

0.3339

0.3339

2.64

0.1 187

Ln(Cmax)

Subject_(Seq.)

22

2. 7868

0.1267

5.09

0.0002

Ln(Cmax)

Treatment

1

0.0226

0.0226

0.91

0.35 13

Ln(Cmax)

Period

1

0.0347

0.0347

1.39

0.2503

Ln(Cmax)

Error

22

0.5474

0.0249

 

 

Ln(AUC0-120)

Sequence

1

0.5136

0.5136

2.52

0.1266

Ln(AUC0-120)

Subject_(Seq.)

22

4.4808

0.2037

12 .85

0.0000

Ln(AUC0-120)

Treatment

1

0.0165

0.0165

1.04

0.3 194

Ln(AUC0-120)

Period

1

0.0310

0.0310

1.96

0.1757

Ln(AUC0-120)

Error

22

0.3488

0.0159

 

 

Ln(AUC0-¥(obs))

Sequence

1

0.5511

0.5511

2.47

0.1304

Ln(AUC0-¥(obs))

Subject_(Seq.)

22

4.9096

0.2232

14.66

0.0000

Ln(AUC0-¥(obs))

Treatment

1

0.0222

0.0222

1.46

0.2404

Ln(AUC0-¥(obs))

Period

1

0.0292

0.0292

1.92

0.180 I

Ln(AUC0-¥(obs))

Error

22

0.3349

0.0152

 

 


Table 2: ANOVA table for period, sequence and treatment effects for the logtransformed data of Cmax, AUC 0-120 and AUC 0-∞(obs)
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