Parameter

Pioglitazone

Metformin

 

Ratio

90% CI

Ratio

90% CI

Ln AUC0-t

95.57

86.15-106.03

100.34

86.68-116.15

Ln AUC0-∞

95.90

85.62-107.41

110.07

94.14-122.71

Ln AUMC0-t

98.93

89.64-109.17

100.12

92.07-108.88

Ln Cmax

98.11

93.34-103.12

94.02

87.64-100.85

Table 4: Comparison of 90% CIs of natural log (ln)-transformed parameters for two formulations (test/reference) of pioglitazone/metformin in healthy Pakistani male volunteers.
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