Parameter

Liq.Tc:Oleic

10%DPY patch

Control patch

Cmax (ng/ml)

514.8 ± 150.83

219.0 ± 36.5

20.2 ± 2.0

tmax (min.)

114.0 ± 13.41

408.0 ± 107.3

204.0 ± 32.8

Kel (min-1)

0.0012 ± 0.0005

0.0030 ± 0.0004

0.0010 ± 0.0005

t1/2 (min.)

571.1 ± 24.8

264.2 ± 36.1

620.6 ± 293.5

AUCinf (ng*min/ml)

485972 ±148347

124636 ± 19811

20715 ± 9357

MRT (min.)

880.3 ± 18.2

527.9 ± 30.9

929.1 ± 442.4


All formulae between the same brackets are not significantly different from each other but differ significantly from those included in other brackets (P<0.001) Cmax (ng/ml): (Liq.Tc:Oleic) (10%DPY patch) (Control Patch) AUC(0–∞) (ng*min/ml): (Liq.Tc:Oleic) (10%DPY patch) (Control Patch)
Table 1: Pharmacokinetic Parameters of Fenoterol after Transdermal Applications.
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