Quetiapine pharmacokinetic parameters of individual

Subject No.	C_max (ng/ml)	AUC_0-last (ng/ml)	AUC_0-α (ng/ml)	AUC extrapolated (%)	T_max (h)	T_1/2 (h)	Vd/F (L)	CL/F (L/h)
1	856.94	2356.02	2362.49	0.27	1.25	6.22	0.76	0.08
2	875.39	2265.94	2280.10	0.62	0.50	3.43	0.43	0.09
3	840.11	3696.45	3724.08	0.74	1.00	3.36	0.26	0.05
4	432.69	2631.81	2646.80	0.57	0.75	5.47	0.60	0.08
5	494.32	1821.92	1827.88	0.33	0.75	5.66	0.89	0.11
6	238.63	2097.62	2103.26	0.27	0.75	5.50	0.75	0.10
7	610.9	2201.53	2207.99	0.29	0.75	5.70	0.75	0.09
8	431.64	2706.54	2712.34	0.21	3.00	4.93	0.53	0.07
9	641.20	3978.72	4022.41	1.09	4.00	3.41	0.24	0.05
10	595.4	1984.84	1987.69	0.14	0.50	4.57	0.66	0.10
11	726.20	2424.22	2430.96	0.28	0.50	5.19	0.62	0.08
12	192.13	893.50	903.24	1.08	0.75	8.43	2.69	0.22
13	278.33	1665.92	1672.78	0.41	4.00	5.49	0.95	0.12
14	422.38	2270.07	2275.18	0.22	1.75	4.75	0.60	0.09
15	1585.30	4506.01	4513.05	0.16	0.75	5.22	0.33	0.04
16	662.83	2170.06	2210.26	1.82	1.50	5.22	0.68	0.09
17	664.02	2963.26	2964.87	0.05	0.75	4.20	0.41	0.07
18	504.64	3722.96	3818.17	2.49	2.50	4.22	0.32	0.05
19	535.34	3103.09	3112.80	0.31	3.00	6.20	0.57	0.06
20	444.85	1272.01	1275.88	0.30	0.75	7.33	1.66	0.16
21	663.90	3348.58	3355.58	0.21	0.75	4.95	0.43	0.06
22	422.13	1297.86	1313.70	1.21	0.50	4.05	0.89	0.15
23	922.45	4412.69	4424.12	0.26	0.50	5.06	0.33	0.05
24	1132.80	3213.43	3220.30	0.21	0.75	5.11	0.46	0.06
Mean	632.27	2625.21	2640.25	0.56	-	5.15	0.70	0.09
S.D.	304.43	972.14	979.10	0.59	-	1.17	0.52	0.04
Median	-	-	-	-	0.75	-	-	-
Max.	-	-	-	-	4.0	-	-	-
Min.	-	-	-	-	0.5	-	-	-

Table 2: Quetiapine pharmacokinetic parameters of individual subject after a single oral dose of 200 mg of Ketipinor^®.

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