Dependent variable Source of variation   df   Sum of squares   Mean squares Fstat P- values Cmax Subject*Sequence 22 5.189 0.236 2..213 0.034*   Period 1 0.238 0.238 2.229 0.150   Drug 1 0.106 0.106 0.997 0.329   Error 22 2.345 0.107       Total 48 1,958.545       AUC0-last Subject*Sequence 22 4.416 0.201 3.662 0.002*   Period 1 0.023 0.023 0.417 0.525   Drug 1 0.000 0.000 0.006 0.941   Error 22 1.206 0.055       Total 48 2,920.980       AUC0-∞ Subject*Sequence 22 4.674 0.212 3.215 0.004*   Period 1 0.048 0.048 0.733 0.401   Drug 1 0.010 0.010 0.148 0.704   Error 22 1.454 0.066       Total 48 2,917.259

Table 3: Two-way ANOVA studies of natural log-transformed data of ratio of Cmax, AUC0-last and AUC0-∞ of Seroquel® and Ketipinor®.

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