parameters and statistical comparison of minocycline

Parameter

Test product
mean (SD)

Reference product
mean (SD)

Mean ratio of T/R
(90% CI)

Wilcoxon
matched-pairs / paired - t

AUC_t (ng.h/mL)
AUC_inf (ng.h/mL)
C_max (ng/mL)
t_max (h)
t_½ (h)

17272.46 (3316.80)
19438.68 (3862.36)
938.75 (192.92)
2.00 (0.67 – 3.00)*
19.46 (4.90)

16999.33 (3103.27)
19078.66 (3401.97)
944.19 (188.56)
2.00 (1.00 – 3.00)*
18.90 (4.84)

101.36% (97.85 – 105.00)%
101.53% (98.31 – 104.85)%
99.22% (95.92 – 102.63)%
–
–

–
–
–
NS
NS

* Median (range)
NS = not significantly different

Table 1: Pharmacokinetic parameters and statistical comparison of minocycline after 100 mg minocycline capsule single dose administration of the test and reference drug in 20 healthy volunteers.

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