Pharmacokinetic Parameters Geometric mean ± SD (CV%)
Fasting Condition* Non-Fasting Condition**
Test (A) Reference (B) Test (A) Reference (B)
Cmax (ng/mL) 1158.124 ± 518.249 (44.75) 1227.654 ± 653.981 (53.27) 1387.719 ± 554.165 (39.93) 1409.831 ± 517.194 (36.69)
AUC0-t (ng.hr/mL) 5417.395 ± 2681.840 (49.50) 5562.313 ± 2945.785 (52.96) 6285.005 ± 2155.759 (34.30) 6793.396 ± 2604.046 (38.33)
AUC0-∞ (ng.hr/mL) 5789.848 ± 2746.581 (47.44) 5890.051 ± 3016.390 (51.21) 6523.251 ± 2219.038 (34.02) 7057.526 ± 2670.944 (37.85)
Tmax (hr) 1.920 ± 0.878 (45.70) 1.976 ± 1.197 (60.58)  2.729 ± 1.177 (43.13)  2.771± 1.130 (40.78)
Kel (1/hr) 0.121 ± 0.048 (39.89) 0.134 ± 0.050 (37.78) 0.155 ± 0.067 (43.26)  0.155± 0.055 (35.25)
T1/2 (hr) 6.181 ± 4.233 (58.95) 6.410 ± 3.947 (61.57)  5.179 ± 1.982 (38.26)  5.389 ± 3.372 (62.56)
MRT (hr) 5.664 ±  0.677 (11.95) 5.734 ±  1.273  (22.20) 5.699 ±  1.074  (18.85) 5.941 ± 1.012 (17.03)
AUC0-t/AUC0-∞ 92.740 ± 6.027 (6.50) 94.062 ±  4.935 (5.25) 96.270 ± 2.140  (2.22) 95.980 ±  4.850 (5.05)
*N= 36 for fasting study and ** N=34 for non-fasting study; CV = Coefficient of Variance
Table 2: Mean pharmacokinetic parameters of acyclovir following oral administration of Test and Reference products over 24 hr under fasting and non-fasting conditions.
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