| Pharmacokinetic Parameters |
Geometric mean ± SD (CV%) |
| Fasting Condition* |
Non-Fasting Condition** |
| Test (A) |
Reference (B) |
Test (A) |
Reference (B) |
| Cmax (ng/mL) |
1158.124 ± 518.249 (44.75) |
1227.654 ± 653.981 (53.27) |
1387.719 ± 554.165 (39.93) |
1409.831 ± 517.194 (36.69) |
| AUC0-t (ng.hr/mL) |
5417.395 ± 2681.840 (49.50) |
5562.313 ± 2945.785 (52.96) |
6285.005 ± 2155.759 (34.30) |
6793.396 ± 2604.046 (38.33) |
| AUC0-∞ (ng.hr/mL) |
5789.848 ± 2746.581 (47.44) |
5890.051 ± 3016.390 (51.21) |
6523.251 ± 2219.038 (34.02) |
7057.526 ± 2670.944 (37.85) |
| Tmax (hr) |
1.920 ± 0.878 (45.70) |
1.976 ± 1.197 (60.58) |
2.729 ± 1.177 (43.13) |
2.771± 1.130 (40.78) |
| Kel (1/hr) |
0.121 ± 0.048 (39.89) |
0.134 ± 0.050 (37.78) |
0.155 ± 0.067 (43.26) |
0.155± 0.055 (35.25) |
| T1/2 (hr) |
6.181 ± 4.233 (58.95) |
6.410 ± 3.947 (61.57) |
5.179 ± 1.982 (38.26) |
5.389 ± 3.372 (62.56) |
| MRT (hr) |
5.664 ± 0.677 (11.95) |
5.734 ± 1.273 (22.20) |
5.699 ± 1.074 (18.85) |
5.941 ± 1.012 (17.03) |
| AUC0-t/AUC0-∞ |
92.740 ± 6.027 (6.50) |
94.062 ± 4.935 (5.25) |
96.270 ± 2.140 (2.22) |
95.980 ± 4.850 (5.05) |
