Sources of Variations

C_max
(μg/ml)

T_max
(hr)

AUC_0-12 (hr-μg/ml)

AUC_0-∞
(hr-μg/ml)

K_el
(hr^-1)

t_1/2
(hr)

AUMC_0-12
(hr²-μg/ml)

AUMC_0-∞
(hr²-μg/ml)

MRT
(hr)

Formulation

0.111

0.829

0.781

0.829

0.644

0.660

0.506

0.721

0.674

Period

0.641

0.510

0.971

0.944

0.966

0.967

0.721

0.678

0.366

Sequence

0.704

0.968

0.758

0.831

0.407

0.431

0.994

0.876

0.620

Subjects

<0.01

0.663

<0.01

<0.01

0.067

0.074

<0.01

<0.01

0.099