Desvenlafaxine Metabolite LC/MS Response

Treatment Group (Subject Number)	Dose (mg)	Time Point (h)	Metabolite to Desvenlafaxine LC/MS Peak Area Ratio			Estimated Desvenlafaxine Concentration (ng/mL)
Treatment Group (Subject Number)	Dose (mg)	Time Point (h)	M13	M7	NODV	Estimated Desvenlafaxine Concentration (ng/mL)
A (1, 17)	300	6 12 24	ND	0.29	ND	699
			0.007	0.65	ND	687
			0.011	0.44	ND	314
	600	6 12 24	ND	0.36	ND	1393
			0.006	0.80	0.002	1194
			0.014	0.71	0.007	638
	300	6 12 24	ND	0.27	ND	625
			0.006	0.45	ND	499
			ND	0.35	ND	287
B (6, 11, 16, 19)^a	600	6 12 24	ND	0.33	ND	1301
			0.005	0.48	0.003	1269
			0.004	0.35	0.005	827
	300	6 12 24	ND	0.21	ND	663
			ND	0.34	ND	621
			ND	0.23	ND	362
E (4, 12, 13, 23)	600	6 12 24	ND	0.31	0.002	1345
			0.004	0.48	0.003	1230
			0.005	0.28	0.005	787

Table 2: Desvenlafaxine Metabolite LC/MS Response Relative to Desvenlafaxine in Pooled Plasma Samples From Healthy Volunteers After a Single Oral Dose of Desvenlafaxine 300 mg or 600 mg.

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