Exposure times of  PC

Groups

Activity of MnSOD
[NU/mg. p]

Activity of Cu/ZnSOD [NU/mg. p]

Activity of GPX
[IU/g.p]

Activity of GST
[IU/g.p]

Activity of GR
[IU/g.p]

4 weeks

C
B

15744± 987
12472± 738

54575± 1543
50989± 1383a

758±93,6
699±66,7

509±57,7
558±92,8a

47±4.14
58,6±8.28a

8 weeks

C
B

21505± 423
19414±818b

48871±8132
49184±9196

378±69,3
80±17,5b

412±62.7
804±61b

37±4.16
49.5±10.4a

12 weeks

C
B

15442± 523
10600±790 b

45071± 2449
39664± 1058a

311±5.2
102±8.1b

422±25,4
940±29,1b

47±6.09
85±5.82b

aSignificance of the results, p≤0.05 comparison of control
bSignificance of the results, p≤0.001 comparison of control

Data represent the mean (median) ± SEM; n=10,and were analyzed with student t-test or Mann Whitney U test . Abbreviations: C-control (untreated) group, B – (study group) rats were given paracetamol (acetaminophen) solution to drink by intra-oesophageal instillation in a dose of 2.4 g/kg of body weight/24 hrs (i.e. 16 μmol/kg of body weight/24 hrs), after drinking it, they had unlimited access to distilled water.
Table 1: Activities of superoxide dismutase isoenzymes, glutathione peroxide se, glutathione-S- transferase and glutathione reductase in rat liver.
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