Source of Variation
df
SS
MS
Computed F
P-value
AUC
0–t
Subject
1
0.0431
0.0431
0.1508
0.7010
Subject (sequence)
25
7.1513
0.2861
7.7731
0.0000
Period
1
0.0433
0.0433
1.1776
0.2882
Formulation
1
0.0455
0.0455
1.2373
0.2766
Error
25
0.9200
0.0368
-
-
Total
53
8.2032
-
-
-
AUC
0–∞
Subject
1
0.0222
0.0222
0.0913
0.7651
Subject (sequence)
25
6.0787
0.2431
6.7752
0.0000
Period
1
0.0709
0.0709
1.9759
0.1721
Formulation
1
0.0558
0.0558
1.5552
0.2239
Error
25
0.8972
0.0359
-
-
Total
53
7.1248
-
-
-
C
max
Subject
1
0.0697
0.0697
0.1856
0.6703
Subject (sequence)
25
9.3831
0.3753
4.6666
0.0001
Period
1
0.0591
0.0591
0.7345
0.3996
Formulation
1
0.1014
0.1014
1.2609
0.2721
Error
25
2.0107
0.0804
-
-
Total
53
11.6240
-
-
-
Table 2:
Analysis of variance table of logarithmically transformed AUC
0–t
, AUC
0–∞
and C
max
of test and reference of 40mg furosemide tablets after single-dose administration in healthy male volunteers (N = 27).
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