Parameter Time                   0 - 4 h       4 - 8 h                            8 - 12 h Mean p-value Mean p-value Mean p-value T R T R T R Volume (mL) 1868.93 1701.79 0.2371 307.14 323.21 0.7533 219.82 163.57 0.2555 Sodium (mEq) 127.63 115.13 0.0714 43.29 44.91 0.8267 35.06 27.42 0.3062 Potassium (mEq) 18.94 16.59 0.9498 8.82 10.13 0.3899 10.56 9.35 0.5598 Chlorine (mEq) 244.99 232.87 0.2872 23.82 22.48 0.8200 11.12 6.65 0.2264

Table 4: Statistical Analysis of urine parameters volume, sodium, potassium and chlorine for test (T) and reference (R) formulation.

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