Parameter

RHIIP Value

V/F (mL)

26840

ka (min-1)

0.00492

kcp (min-1)

7.38

kpc (min-1)

512

ke (min-1)

0.0380

Emax (mg/kg/min)

40.6

EC50 (ng/mL)

3.06

kin (mg/kg/min)

0.717

Table 3: Pharmacokinetic and pharmacodynamic parameters obtained using the pharmacokinetic-pharmacodynamic model described in Fig. 1 following inhalation nsulin (RHIIP) administration.
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