Pharmacokinetic Parameter Referencea Meanb Test Meanb Mean Ratio (%) Classic CI (%) Westlake CI (%) Schuirmann Unilateral Double t (%) Anderson-Hauck Test Power
Lower Upper Lower Upper Lower Upper
Cmax, ng/mL                      
CT with water  579.29 526.11 90.82 78.93 104.49 81.41 118.59 0.0680 0.0002 0.0678 0.8365
CT without water 579.29 455.55 78.64 68.35 90.48 70.54 129.46 0.5808 0.0000 0.5808 0.8365
AUC0-t, h•ng/mL                      
CT with water 1714.43 1663.47 97.03 90.94 103.52 92.18 107.82 0.0000 0.0000 0.0000 0.9999
CT without water 1714.43 1525.19 88.96 83.38 94.92 84.61 115.39 0.0041 0.0000 0.0041 0.9999
AUC0-inf, h•ng/mL                      
CT with water 1800.71 1752.02 97.30 91.50 103.46 92.67 107.33 0.0000 0.0000 0.0000 1.0000
CT without water 1800.71 1631.88 90.62 85.23 96.36 86.41 113.59 0.0006 0.0000 0.0006 1.0000
Criterion ≥80 ≤125 ≥80 ≤125 <0.05 <0.05 <0.05 >0.8
CT=chewable sildenafil 100-mg tablet.
aViagra conventional film-coated tablet.
bLeast squares geometric mean.
Table 2: CIs and Limit Tests for Logarithmically Converted Pharmacokinetic Data.
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