Method                         Particle size          Entrapment efficiency         Drug loading
                                           (nm)                     (%)                                  (%)
 

magnetic stirring                    172.6                    47.8                              4.56
(25°C)
rotatory evaporating             156.2                    52.6                              4.99
(25°C )
rotatory evaporator
(37°C)                                   131.2                    56.3                              5.33