Formulation / Pharmacokinetic parameter XR-Fed XR-Fasted IR-Fasted P-value     
Auc0→t (ng.mL /hr) 7143
(1671)		 5795
(2279)		 12459
(3553)		 <0.05          
Auc0→∞ (ng.mL /hr) 7448
(1585) 		6167
(2236)		 12884
(3450)		 <0.05          
Cmax (ng/mL) 794
(143)		 832
(300)		 1956
(476)		 <0.05 *
t1/2 (hr) 3.66
(0.8)		 3.8
(1.2)		 3.39
(0.7)		 >0.05          
Kel (hr-1) 0.2
(0.1)		 0.19
(0.1)		 0.22
(0.1)		 >0.05          
Tmax (hr) 6.35
(1.1)		 4.3
(1.0)		 2.58
(1.0)		 < 0.05
> 0.05 for XR-Fed vs XR-Fast Cmax comparison
Table 1: Metformin mean (SD) plasma pharmacokinetic parameters after 1000 mg IR oral dose/ 750 mg XR oral doses to 78 healthy volunteers under different states.
Goto home»