image
Figure 6: Hypoglycemic activity of Ins-containing microparticles after subcutaneous and peroral administrations to healthy rabbits (4 IU/kg). (×) – 0.15 M NaCl solution, pH 3.0; (□) – Ins solution subcutaneously; (Δ) – microparticles subcutaneously; (●) – microparticles perorally to animals with initial glucose level less than 5.5 mM; (○) – microparticles perorally to animals with initial glucose level over 5.5 mM. * Shows statistically significant difference between animals treated with microparticle (at initial glucose level more than 5.5 mM and control group (untreated), † shows statistically significant difference between animals with initial glucose level over 5.5 mM and less than 5.5 mM (p < 0.05).
Goto home»