paracetamol in fasted and semi-fed states

Parameter	Fasted			Semi-Fed
	Means^[1]		Ratio	Means ^[1]		Ratio
	New	Current	[90% CI]	New	Current	[90% CI]
	(N=30)	(N=30)		(N=30)	(N=30)
C_max	17.36	14.46	1.20	15.12	15.18	1.00
(µg/ml)			[1.11, 1.30]			[0.93, 1.07]
AUC_0-t	53.08	49.59	1.07	48.57	47.38	1.03
(µg∙hr/ml)			[1.05, 1.10]			[1.00, 1.05]
AUC_0-∞	57.54	53.97	1.07	52.95	51.80	1.02
(µg∙hr/ml)			[1.04, 1.09]			[1.00, 1.05]
AUC_0-30min	3.74	1.28	2.93	1.25	0.16	7.68
(µg∙hr/ml)			[2.23, 3.84]			[4.59, 12.85]
AUC_0-60min	11.37	6.63	1.72	6.93	2.31	3.00
(µg∙hr/ml)			[1.46, 2.02]			[2.17, 4.14]

[1] Geometric means are the exponentiated least squares means of log-transformed variables

Table 1: Pharmacokinetic parameters of paracetamol in fasted and semi-fed states (New = PANADOL^® EXTRA ADVANCE; Current = currently-marketed PANADOL EXTRA^®).

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