Parameter

Fasted

Semi-Fed

Means[1]

Ratio

Means [1]

Ratio

New

Current

[90% CI]

New

Current

[90% CI]

(N=30)

(N=30)

(N=30)

(N=30)

Cmax

17.36

14.46

1.20

15.12

15.18

1.00

(µg/ml)

[1.11, 1.30]

[0.93, 1.07]

AUC0-t

53.08

49.59

1.07

48.57

47.38

1.03

(µg∙hr/ml)

[1.05, 1.10]

[1.00, 1.05]

AUC0-∞

57.54

53.97

1.07

52.95

51.80

1.02

(µg∙hr/ml)

[1.04, 1.09]

[1.00, 1.05]

AUC0-30min

3.74

1.28

2.93

1.25

0.16

7.68

(µg∙hr/ml)

[2.23, 3.84]

[4.59, 12.85]

AUC0-60min

11.37

6.63

1.72

6.93

2.31

3.00

(µg∙hr/ml)

[1.46, 2.02]

[2.17, 4.14]


[1] Geometric means are the exponentiated least squares means of log-transformed variables
Table 1: Pharmacokinetic parameters of paracetamol in fasted and semi-fed states (New = PANADOL® EXTRA ADVANCE; Current = currently-marketed PANADOL EXTRA®).
Goto home»