Parameter

Fasted

Semi-Fed

Means [1]

Ratio

Means [1]

Ratio

New

Current

[90% CI]

New

Current

[90% CI]

(N=30)

(N=30)

(N=30)

(N=30)

Cmax

3.74

3.44

1.08

3.51

3.42

1.03

(µg/ml)

[1.045, 1.125]

[0.986, 1.068]

AUC0-t

21.85

20.98

1.04

20.52

20.07

1.02

(µg∙hr/ml)

[1.020, 1.064]

[0.999, 1.046]

AUC0-∞

31.65

30.79

1.03

30.44

30.23

1.01

(µg∙hr/ml)

[0.990, 1.067]

[0.963, 1.052]

AUC0-30min

0.78

0.38

2.05

0.26

0.09

2.97

(µg∙hr/ml)

[1.699, 2.484]

[2.119, 4.154]

AUC0-60min

2.52

1.80

1.40

1.56

0.69

2.28

(µg∙hr/ml)

[1.268, 1.552]

[1.786, 2.905]


[1] Geometric means are the exponentiated least squares means of log-transformed variables
Table 2: Pharmacokinetic parameters of caffeine in fasted and semi-fed states (New = PANADOL®EXTRA ADVANCE; Current = currently-marketed PANADOL EXTRA®).
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