Parameters

Units

Formulations

P-value

Flonicol®
(Test)

Veterin®10% (Reference)

Cmax

µg/ml

9.02±0.68

9.20±0.77

0.839

tmax

h

1.02±0.13

1.05±0.30

0.899

t1/2β

h

1.41±0.06

1.35±0.05

0.407

AUC0-12h

µg.h/ml

26.45±1.33

26.06±1.20

0.803

AUC0-∞

µg.h/ml

26.61±1.33

26.26±1.21

0.821

AUMC

µg.h2/ml

71.78±4.65

69.98±8.80

0.832

MRT

h

2.72±0.18

02.62±0.27

0.723

ClB/F

ml\min\kg

12.82±0.63

12.96±0.60

0.844

Vdz/F

l\kg

1.55±0.08

1.51±0.08

0.692

Cmax, maximum plasma concentration; tmax, time to peak concentration; t1/2β, elimination half-life; AUC0-12h, area under plasma concentration-time curve from zero to 12h post drug administration; AUC0-∞, area under plasma concentrationtime curve from zero to infinity; AUMC, area under the first moment timeconcentration curve; MRT, mean residence time; F, systemic bioavailability; ClB/F, total body clearance/F; Vdz/F, volume of distribution/F.
Table 2: Comparison of the mean plasma pharmacokinetic parameters obtained for florfenicol after single oral administration of Flonicol® (test) and Veterin®10% (reference) formulations to broiler chickens at 20mg/kg bw. Values are expressed as mean ± SE. (n=14).
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