P for Exceeding the Limits of Acceptance for Bioavailability

Compound

Parameter

Ratio  Test/
Reference,%

90% CI

<80%

>125%

Power

clopidogrel

Cmax

94.4

90.26–113.91

0.001

<0.001

0.99

AUC0–t

100.4

91.82–103.27

<0.001

<0.001

0.99

AUC0–∞

102.0

93.67–106.89

<0.001

<0.001

0.99

SR26334

Cmax

90.1

85.23–112.97

0.002

<0.001

0.99

AUC0–t

95.6

93.11–103.67

<0.001

<0.001

0.99

AUC0–∞

95.8

88.67–101.53

<0.001

<0.001

0.99

Table 2: Comparison of 90% Cls of natural log (ln)-transformed parameters for clopidogrel and SR26334 following administration of 2 formulations (Test/Reference) of clopidogrel tablets in healthy Chinese male volunteers.
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