Unconjugated (% dose)

Total unconjugated and conjugated (% dose)

Treatment Group

Variables

(R+S)-Desvenlafaxine

NODV

CLR
mL/min

(R+S)-Desvenlafaxine

NODV

Sum Total (R+S)-Desvenlafaxine and NODV

IV desvenlafaxine
50 mg/h

Mean (SD)
%CV
Geo. Mean
Min-Max

51.5 (11.4)
22%
50.0
22.0-63.8

1.6 (1.1)
67%
1.1
0.1-3.5

202 ± 96
47%
185
85-468

72.3 (14.5)
20%
70.5
32.6-88.7

3.6 (1.2)
34%
3.3
1.0-5.2

75.9 (15.1)
20%
74.0
33.6-93.8

Oral desvenlafaxine
100 mg

Mean (SD)
%CV
Geo. Mean
Min-Max

46.4 (9.9)
21%
45.3
24.5-64.6

1.9 (1.0)
55%
1.5
0.2-3.9

222 ± 82
37%
211
145-454
 

65.5 (10.8)
17%
64.5
39.4-76.3

3.5 (1.3)
38%
3.3
1.4-6.6

69.0 (11.8)
17%
67.9
40.9-82.9

Abbreviations: % dose: Percent of the Dose of Study Drug Given, which is a Combination of Both (R)- and (S)-Enantiomers; CLR: Renal Clearance; CV: Coefficient of
Variation; Geo. Mean: Geometric Mean; IV: Intravenous; Max: Maximum; Min: Minimum; NODV: N,O-Didesmethylvenlafaxine; SD: Standard Deviation
Table 3: Urinary Recovery of Unconjugated and Conjugated (R+S)-Desvenlafaxine and Unconjugated and Conjugated NODV.
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