Plasma Pharmacokinetic Parameters Following a Single

*Parameter*	*Dosing Condition*
	Fasting	Fed
	Fasting	Low-fat meal*	Medium-fat meal	High-fat meal
C_max (ng/ml)	433 ± 111 (26) [419]	471 ± 117 (25) [455]	463 ± 118 (26) [447]	500 ± 121 (24) [483]
t_max (h)†	6.00 (4.00, 24.00)	10.00 (4.00, 16.00)	8.00 (4.00, 16.00)	8.00 (6.00, 12.00)
t_½ (h)	10.73 ± 1.69 (16) [10.60]‡	10.64 ± 1.74 (16) [10.49]	11.04 ± 4.68 (42) [10.53]	10.39 ± 2.13 (21) [10.18]
AUCT (ng*h/ml)	11019 ± 2863 (26) [10541]‡	10797 ± 2496 (23) [10434]	11200 ± 2346 (21) [10907]	10507 ± 2609 (25) [10096]
AUC (ng*h/ml)	11245 ± 2936 (26) [10759]‡	10995 ± 2558 (23) [10624]	11496 ± 2562 (22) [11170]	10683 ± 2703 (25) [10259]
Cl/F (L/h)	19.90 ± 9.91 (50) [18.59]‡	19.81 ± 8.32 (42) [18.83]	18.6 ± 6.38 (34) [17.90]	20.68 ± 9.18 (44) [19.50]
Cl/F (L/h/kg)	0.27 ± 0.14 (50) [0.25]‡	0.27 ± 0.10 (39) [0.25]	0.26 ± 0.08 (31) [0.25]	0.28 ± 0.12 (43) [0.26]

AUC: Area Under the Concentration-Versus-Time Curve; AUCT: AUC to the Last Quantifiable Concentration at Time T; Cl/F: Apparent Oral-dose Clearance; C_max: Peak Plasma Concentration; CV: Coefficient of Variation; t_½: Apparent Terminal-phase Elimination Half-life; t_max: Time to C_max.
*One subject in the low-fat treatment group was excluded. †Median (minimum, maximum) for t_max. ‡One subject in the fasting treatment group was excluded.

Table 1: Plasma Pharmacokinetic Parameters Following a Single, Oral, 200 mg Dose of Desvenlafaxine Administered Under Fasting and Fed Dosing Conditions; Mean ± SD (CV%), [Geometric Mean].

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