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Figure 1: Mean plasma concentration-time curves of acyclovir after the administration a single-dose of valacyclovir (500 or 1000 mg). Solid symbols represent the reference-test pair of formulations containing valacyclovir 1000 mg (n = 26). Open symbols represent the reference-test pair of formulations containing 500 mg of valacyclovir (n = 25). Right panel: mean (±SE) concentrations over the first 4 hours after administration. In the study with valacyclovir 500 mg, the trademarks were Rapivir® (GlaxoSmithKline Mexico, S. A. de C. V, Mexico City, Mexico) for the reference formulation and Valextra® for the test formulation. In the study with valacyclovir 1000 mg, the trademarks were Valtrex® (GlaxoSmithKline, Research Triangle Park, North Carolina) for the reference formulation and Valextra® for the test formulation.
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