after a single-dose administration of valacyclovir

	1000 mg		500 mg
Parameter	Reference†	Test*	Reference‡	Test*
No. of subjects	26	26	25	25
C_max, μg/ml	5.59 (1.76)	5.21 (1.60)	3.90 (1.25)	4.10 (1.31)
AUC_0-t, h·μg/ml	20.10 (4.82)	18.87 (4.66)	12.49 (2.89)	12.48 (2.97)
AUC_0-∞, h·μg/ml	20.85 (4.96)	19.53 (4.74)	13.04 (2.88)	13.14 (2.94)
T_max, h	2.15 (0.75)	2.09 (0.61)	1.60 (0.63)	1.58 (0.73)
t_1/2, h	2.46 (0.31)	2.52 (0.49)	2.60 (0.50)	2.59 (0.45)

AUC_0-t = AUC from time 0 (baseline) to the last measurable concentration
AUC_0-∞ = AUC from baseline extrapolated to infinity
*Trademark: Valextra^® (Laboratorios Liomont, S.A. de C.V., Mexico City, Mexico)
†Trademark: Valtrex^® (GlaxoSmithKline, Research Triangle Park, North Carolina)
‡Trademark: Rapivir^® (GlaxoSmithKline Mexico, S.A.de C.V.,Mexico City, Mexico)

Table 1: Pharmacokinetic parameters of acyclovir after a single-dose administration of valacyclovir (500 mg or 1000 mg) in healthy Mexican adult subjects. Values are mean (SD).

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