Parameter Geometric Mean
Ratio (%)
90% CI Probability of Exceeding Limits of Acceptance Power
P<80% P>125%
Valacyclovir 1000 mg          
Cmax 93.26 86.22-100.87 <0.01 <0.01 1.00
AUC0-t, 93.69 89.11-98.50 <0.01 <0.01 1.00
AUC0-∞ 93.55 89.00-98.34 <0.01 <0.01 1.00
Valacyclovir 500 mg          
Cmax 104.8 95.24-115.33 <0.01 <0.01 0.98
AUC0-t, 99.81 96.20-103.55 <0.01 <0.01 1.00
AUC0-∞ 100.66 97.12-104.34 <0.01 <0.01 1.00
AUC0-t = AUC from time 0 (baseline) to the last measurable concentration
AUC0-∞ = AUC from baseline extrapolated to infinity
Table 2: Geometric mean ratios, 90% CIs, the probabilities of exceeding the limits of acceptance (80%-125%) and the power test results of the pharmacokinetic parameter determined for acyclovir after a single-dose administration of valacyclovir (500 mg or 1000 mg) in healthy Mexican adult subjects.
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