Brain Zones

Control 1 (intact animals)

DW
injection

%

P value

Control 2
(PS
injection)

%

P value

Mannitol
injection

%

P value

Hydration [water cont. g/g d.w.] (mg.)

Cortex

2.82 ± 0.05

4.4 ± 0.074

↑42

P = 0,4

3.1 ± 0.0374

↑10

P =0,0000078

2.28 ± 0.022

26.5

P = 0,00039

Stem

3.09 ± 0.075

3.5 ± 0.072

↑34

P = 0,3

2.6 ± 0.055

↓15.8

P = 0,000025

2.28 ± 0.018

12.3

P = 0,0006

Cerebellum

2.75 ± 0.041

3.2 ± 0.08

↑23

P = 0,8

2.6 ± 0.06

↓5.5

P = 0,0001

2.145 ± 0.019

17.5

P = 0,053

x107 molecule g/ d.w.

Cortex

19 ± 0.18

30.4 ± 0.027

↑45

P = 0,011

20.9 ± 0.13

↑10

P = 0,0000067

15.2 ± 0.8

27

P = 0,00025

Stem

17 ± 0.22

19.8 ± 0.021

↑38

P = 0,013

14.3 ± 0.16

↓15.8

P = 0,000033

12.84 ± 0.5

10.2

P = 0,0001

Cerebellum

22 ± 0.2

25.69 ± 0.04

↑23

P = 0,1

20.87 ± 0.3

↓5.1

P = 0,0005

16.05 ± 0.9

23

P = 0,034

Table 1: Correlation between brain tissues hydration and the number of ouabain molecules in experiments with intraperitoneally injected distilled water (DW), physiological solution (PS) and mannitol.
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