Rilpivirine PK Parameter Test Formulation 1
(n = 34)a
Reference Formulation
(n = 34)a
Cmax (ng/mL), mean (%CV) 116 (29.6) 99.8 (30.5)
Tmax (hours), median (Q1, Q3) 4.50 (4.00, 4.50) 4.50 (4.00, 4.50)
Clast (ng/mL), mean (%CV) 4.1 (72.9) 3.4 (72.8)
Tlast (hours), median (Q1, Q3) 192 (192, 193) 192 (192, 192)
AUC0-last (ng•h/mL), mean (%CV) 3010 (34.5) 2600 (32.5)
AUCinf (ng•h/mL), mean (%CV) 3390 (39.4) 2920 (38.6)
%AUCexp, mean (%CV) 9.5 (68.5) 9.6 (69.3)
T1/2 (hours), median (Q1, Q3) 54.2 (39.0, 62.9) 53.1 (40.2, 65.5)
%CV = % coefficient of variation; PK = pharmacokinetic; Q1 = first interquartile; Q3 = third interquartile
Data presented in 3 significant figures.
a: Two subjects were excluded from the PK analysis set due to premature discontinuation from the study.
Table 2: .
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