a)
     Healthy                                    Tissue hydration (water content g/g dry mass)
     Organ Ouabain concentration (M)          
        0        10-11      Δ%  Ouabain 10-8M      Δ%  Ouabain 10-6M      Δ%
Heart muscle 2.389±0.1 2.422±0.02 ↑1.38 2.7±0.26 ↑13.02 2.306±0.05 ↓3.47
Skeletal muscle 2.357±0.23 2.338±0.12 ↓0.8 3.361±0.25 ↑42.6 3.421±0.3 ↑45.14
Lung 2.199±0.15 2.385±0.15 ↑8.4 2.243±0.06 ↑2.01 2.167±0.3 ↓1.46
Liver 2.054±0.12 2.337±0.22 ↑13.78 2.547±0.18 ↑24.01 2.92±0.17 ↑42.16
Spleen 2.225±0.13 1.567±0.08 ↓29.57 2.444±0.25 ↑9.84 3.147±0.3 ↑41.44
Kidney 2.05±0.13 1.722±0.08 ↓16.04 2.878±0.19 ↑40.32 3.09±0.15 ↑50.66
b)
Sarcoma carrying                                         Tissue hydration (water content g/g dry mass)
          Organ Ouabain concentration (M)          
          0         10-11      Δ%  Ouabain 10-8M      Δ%  Ouabain 10-6M      Δ%
Heart muscle 3.3±0.1 3.25±0.01 ↓1.5 2.5±0.01 ↓24.24 3±0.01 ↓9.09
Skeletal muscle 3.87±0.21 2.64±0.14 ↓31.78 4.63±0.33 ↑19.64 4.41±0.23 ↑13.95
Lung 3.31±0.03 3.62±0.21 ↑9.37 5.75±0.18 ↑73.72 3.67±0.23 ↑10.88
Liver 3.265±0.15 2.95±2.27 ↓9.64 3.88±0.35 ↑18.84 3.94±0.22 ↑20.67
Spleen 2.8±0.14 2.7±0.14 ↓3.57 2.93±0.33 ↑4.64 3.14±0.23 ↑12.14
Kidney 3.357±0.19 3.52±0.16 ↑4.86 3.56±0.16 ↑6.05 3.44±0.16 ↑20.47
Sarcoma 180 4.8±0.33 4.4±0.4 ↓8.33 5.66±0.28 ↑17.92 4.97±0.32 ↑3.54
Table 2: The effect of ouabain (at 10-11, 10-8 and 10-6M concentrations) on tissue hydration of different organs: a) healthy mice; b) sarcoma-180 carrying mice.
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