a)
         Organ                                                                                         Ouabain concentration (M)
                            0                       10-11                       10-8                       10-6

control

cisPt Δ% control cisPt Δ% control cisPt Δ% control cisPt Δ%
Heart muscle 2.39 ±0.1 1.93 ±0.15 ↓19.07 2.42 ±0.02 1.38 ±0.12 ↓42.89 2.7 ±0.26 1.99 ±0.13 ↓26.1 2.3 ±0.05 2.47 ±0.19 ↑7.3
Skeletal muscle 2.36 ±0.23 3.08 ±0.21 ↑30.47 2.34 ±0.06 2.76 ±0.12 ↑18.23 3.36 ±0.25 3.25 ±0.29 ↓3.2 3.42 ±0.3 3.76 ±0.27 ↑9.95
Lung 2.2 ±0.15 1.21 ±0.11 ↓45.06 2.39 ±0.15 0.88 ±0.11 ↓63.17 2.24 ±0.06 1.11 ±0.12 ↓50.5 2.17 ±0.17 1.69 ±0.16 ↓22.15
Liver 2.05 ±0.12 2.27 ±0.12 ↑10.24 2.34 ±0.22 2.32 ±0.19 ↓0.74 2.55 ±0.18 2.98 ±0.2 ↑17.2 2.92 ±0.17 2.43 ±0.17 ↓16.94
Spleen 2.23 ±0.13 2.13 ±0.12 ↓4.12 1.57 ±0.17 1.6 ±0.15 ↑2.13 2.44 ±0.13 1.55 ±0.07 ↓36.6 3.15 ±0.26 1.75 ±0.14 ↓44.4
Kidney 2.05 ±0.13 2.05 ±0.12 ↓0.12 1.72 ±0.08 2.41 ±0.13 ↑39.85 2.88 ±0.19 2.46 ±0.18 ↓14.6 3.09 ±0.15 2.67 ±0.19 ↓13.73
b)
         Organ                                                                                         Ouabain concentration (M)
                             0                       10-11                       10-8                       10-6
control cisPt Δ% control cisPt Δ% control cisPt Δ% control cisPt Δ%
Heart muscle 3.3 ±0.1 3.34 ±0.08 ↑1.3 3.25 ±0.1 2.55 ±0.07 ↓21.54 2.5 ±0.4 2.88 ±0.15 ↑15 3 ±0.12 3.05 ±0.18 ↑1.67
Skeletal muscle 3.87 ±0.21 4.07 ±0.18 ↓30.91 3.53 ±0.14 4.78 ±0.16 ↑15.37 4.62 ±0.33 4.74 ±0.16 ↓6.72 4.41 ±0.23 4.81 ±0.31 ↑1.46
Lung 3.31 ±0.03 2,83 ±0.13 ↓14.39 2.64 ±0.21 3.1 ±0.14 ↑17.54 5.75 ±0.18 3.25 ±0.15 ↓43.48 3.67 ±0.15 2.5 ±0.19 ↓31.81
Liver 3.27 ±0.15 2.4 ±0.17 ↓26.43 3.62 ±0.27 2.98 ±0.1 ↓17.58 3.88 ±0.35 3.58 ±0.2 ↓7.76 3.94 ±0.15 3.92 ±0.12 ↓0.55
Spleen 2.8 ±0.14 2.42 ±0.12 ↓13.69 2.95 ±0.06 1.88 ±0.19 ↓36.54 2.93 ±0.13 2.33 ±0.01 ↓20.33 3.14 ±0.19 2.86 ±0.2 ↓8.98
Kidney 3.36 ±0.19 2.25 ±0.2 ↓32.98 2.69 ±0.16 2.85 ±0.25 ↑5.81 3.56 ±0.16 3.17 ±0.24 ↓10.94 3.44 ±0.15 2.88 ±0.18 ↓16.36
Sarcoma-180 4.8 ±0.33 4.08 ±0.35 ↓15.16 4.41 ±0.4 4.78 ±0.15 ↓8.37 5.66 ±0.23 4.74 ±0.23 ↓16.25 4.98 ±0.32 4.81 ±0.36 ↓3.25
Table 4: The effect of cisPt on tissue hydration of different organs: a) healthy mice; b) sarcoma-180 carrying mice.
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