a)

Organ                                                                 Ouabain concentration (M)                         10-11                             10-8                            10-6 control cisPt Δ% control cisPt Δ% control cisPt Δ% Heart muscle 18.11 ±0.41 18.33 ±0.55 ↑1.2 21.46 ±0.64 20.72 ±0.52 ↓3.45 25.14 ±0.49 25.11 ±0.28 ↓0.13 Skeletal muscle 16.65 ±0.38 16.58 ±0.83 ↓0.4 18.8 ±0.51 19.8 ±0.28 ↑5.3 23.75 ±0.51 24.05 ±0.68 ↑1.25 Lung 18.45 ±0.75 18.67 ±0.33 ↑1.21 21.44 ±1.06 21.37 ±0.53 ↓0.33 26.04 ±0.77 25.91 ±0.22 ↓0.5 Liver 17.39 ±0.38 17.66 ±0.68 ↑1.54 18.77 ±0.55 19.97 ±0.38 ↑6.38 24.25 ±0.45 24.65 ±0.55 ↑1.64 Spleen 18.49 ±0.63 18.69 ±0.67 ↑1.15 21.56 ±0.46 21.04 ±0.55 ↓2.43 24.99 ±0.48 25.43 ±0.29 ↑1.75 Kidney 17.06 ±0.61 17.52 ±0.18 ↑2.69 19.94 ±0.61 19.92 ±0.15 ↓0.1 23.75 ±0.52 24.55 ±0.42 ↑0.26

b)

Organ                                                                 Ouabain concentration (M)                         10-11                         10-8                         10-6   control cisPt Δ% control cisPt Δ% control cisPt Δ% Heart muscle 18.67 ±0.11 18.88 ±0.76 ↑1.1 20.72 ±0.11 21.37 ±0.81 ↑3.17 25.87 ±0.11 26.27 ±0.65 ↑1.56 Skeletal muscle 17.28 ±0.39 18.41 ±0.74 ↑6.49 20.03 ±0.87 20.62 ±0.25 ↑2.9 24.67 ±0.26 24.75 ±0.42 ↑0.33 Lung 18.23 ±0.59 20.45 ±0.35 ↑12.18 21.92 ±0.29 21.57 ±0.61 ↓1.62 25.52 ±0.29 26.73 ±0.81 ↑4.74 Liver 15.79 ±0.48 18.52 ±0.73 ↑17.26 18.97 ±0.35 20.39 ±0.23 ↑7.46 23.52 ±0.08 25.06 ±0.44 ↑6.54 Spleen 17.32 ±1.14 19.81 ±0.46 ↑14.4 20.64 ±1.22 21.22 ±0.37 ↑2.84 25.19 ±1.81 26.41 ±0.41 ↑4.87 Kidney 16.95 ±0.43 19.09 ±0.81 ↑12.67 19.64 ±0.09 20.62 ±0.32 ↑5.08 24.61 ±0.66 25.21 ±0.69 ↑2.45 Sarcoma-180 16.64 ±0.68 18.43 ±0.54 ↑10.76 19.88 ±0.75 19.75 ±0.34 ↓0.66 24.41 ±0.33 25.04 ±0.26 ↑2.63

Table 5: The effect of cisPt on ouabain binding with cell membrane (number of ouabain molecules/mg dry mass (Ln)) of different organs of a) healthy mice; b) sarcoma-180 carrying mice.

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