Time (hours)  
IR F-1* (10%) F-2* (20%) F-3* (30%) F-4* (40%) F-5* (50%)
0 0 0 0 0 0 0
0.25 74.23 - - - - -
0.5 105.12 18.8 20 22.43 7.67 4.30
0.75 107.25 - - - - -
1.0 109.23 37.7 40.14 27.87 15.45 11.27
1.5 - 56.62 45.66 55.44 23.5 18.12
2.0 - 75.47 50.11 79.56 31.9 22.16
2.5 - 94.45 60.12 95.17 39.1 25.29
3.0 - 94.12 94.11 99.12 46.99 30.71
4.0 - 94.22 90.46 93.11 58.8 66.37
6.0 - 94.5 91.75 89.83 74.5 75.23
8.0 - 94.40 91.75 94.52 84.91 77.39
10.0 - - - - 91 78.9
12.0 - - - - 93.7 78.8
18.0 - - - - 93.6 78.5
24.0 - - - - 93.7 78.5
*All values represent mean (n=6)±SD
Table 3: In vitro release profile of Losartan Potassium from Xanthan gum matrices (IR and F-1 to F-5).
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