statistical analysis of pharmacokinetic

Parameter (units)	Test^a	Reference^a	Ratio (%)^b	90% Confidence Interval
Parameter (units)	Test^a	Reference^a	Ratio (%)^b	Lower	Upper
Azithromycin
C_max (ng/mL)	496	437	113	91.6	141
AUC_last (ng•h/mL)	3910	3880	101	85.4	119
Chloroquine
C_max (ng/mL)	95.8	108	89.0	74.4	106
AUC_last (ng•h/mL)	3250	3281	99.1	84.0	117

Test=2×azithromycin 250 mg/chloroquine 155 mg fixed-combination tablet.
Reference=commercially available azithromycin 500 mg tablet+chloroquine 300 mg tablet.
C_max=maximum concentration
AUC_last=area under the drug concentration–time profile from time zero to the time of last quantifiable concentration
^aAdjusted geometric mean values.
^bRatio of adjusted geometric means.

Table 4: Summary of statistical analysis of pharmacokinetic parameters AUC_last and C_max.

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