Model Parameters R T F1 F2 F3 F4 F5 Zero-order R2 0.6955 0.532 0.1544 -0.0501 -0.1599 0.3686 0.6506 R2-adj 0.6955 0.532 0.1544 -0.0501 -0.1599 0.3686 0.6506 First-order R2 0.9742 0.9989 0.9668 0.9466 0.9873 0.9903 0.9967 R2-adj 0.9742 0.9989 0.9668 0.9466 0.9873 0.9903 0.9967 Higuchi R2 0.9389 0.9566 0.9019 0.8462 0.7975 0.9338 0.9809 R2-adj 0.9389 0.9566 0.9019 0.8462 0.7975 0.9338 0.9809 Korsmeyer-Peppas R2 0.9392 0.9634 0.9833 0.9861 0.963 0.9635 0.9813 R2-adj 0.9305 0.9589 0.9812 0.9844 0.9584 0.959 0.9789 n 0.5130 0.445 0.337 0.298 0.285 0.393 0.487 Hixson-Crowell R2 0.9921 0.9896 0.937 0.8937 0.9224 0.9645 0.9919 R2-adj 0.9921 0.9896 0.937 0.8937 0.9224 0.9645 0.9919

Table 11: Results of model fitting of drug release of Reference (R), Test (T) and fabricated formulations (F1-F5) in 0.1 N HCl.

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