Desvenlafaxine Pharmacokinetic Parameters

Treatment	C_max (ng/mL)	T_max (h)	t_1/2 (h)	AUC (ng•h/mL)	Cl/F (L/h/kg)
100 mg	234 171-326	7.28 4.0-12.0	11.1 9.1-14.2	5376 2649-7516	0.236 0.146-0.523
300 mg	701 474-938	7.01 4.0-12.0	10.9 8.9-14.2	16215 10195-21958	0.233 0.156-0.331
600 mg	1409 1147-1992	8.11 6.0-12.0	11.0 8.4-14.2	34880 23572-46829	0.218 0.141-0.302
3-Period Crossover Analysis of Variance Log-Transformed Data^b
Sequence	<0.001	0.735	0.008	<0.001	<0.001
Subject (sequence)	<0.001	0.367	<0.001	<0.001	<0.001
Treatment	0.759	0.226	0.670	0.121	0.121
Period	0.960	0.894	0.767	0.564	0.564

AUC, area under the plasma concentration-time curve; Cl/F, apparent oral-dose clearance; C_max, peak drug concentration; T_max, time of peak concentration; t_1/2, terminal-phase elimination half-life.
^aData shown is geometric mean, minimum – maximum.
^bBefore statistical comparisons were made, dose-dependent values (C_max and AUC) were normalized to the lowest dose.

Table 2: Desvenlafaxine Pharmacokinetic Parameters, ^aStudy 1 (Single-Dose Proportionality Study).

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