| Desvenlafaxine Dosage |
Cmax
(ng/mL) |
Tmax
(h) |
Cmin
(ng/mL) |
t1/2
(h) |
AUCss
(ng•h/mL) |
Cl/F
(L/h/kg) |
| 300 mg |
796
566-1067 |
4.4
3-6 |
408
268-567 |
10.8
7.8-15.0 |
14577
10856-18429 |
0.25
0.16-0.35 |
| 450 mg |
1339
959-1677 |
6.4
3-20 |
670
433-902 |
11.3
8.9-15.3 |
23418
16649-29915 |
0.25
0.17-0.35 |
| p values from the 1-factor ANOVA with log-transformed parametersa |
| |
0.228 |
0.118 |
0.519 |
0.711 |
0.556 |
0.963 |
ANOVA, analysis of variance; AUCss, area under the steady-state plasma concentration-time curve; Cl/F, apparent oral-dose clearance; Cmax, peak drug concentration; Cmin, minimal drug concentration; SD, standard deviation; t1/2, terminal-phase elimination half-life; Tmax, time of peak concentration.
aData shown are geometric mean, minimum-maximum.
bPrior to statistical comparisons, dose-dependent parameters (Cmax, Cmin and AUCss) were dose-normalized to the 300-mg dose. |
