Parameters        Units                                                       Enromic® 10%                        Enrofloxacin                        Ciprofloxacin     1st Dose 3rd Dose 1st Dose 3rd Dose Cmax µg mL-1 0.450 ± 0.076 0.428 ± 0.119 0.023 ± 0.012 0.023 ± 0.006 Tmax h 2.800 ± 0.633 5.000 ± 0.000 4.300 ± 2.627 6.000 ± 2.108 λZ h-1 0.102 ± 0.046 0.084 ± 0.029 0.073 ± 0.030 0.052 ± 0.016 AUC0 → t µg h mL-1 4.568 ± 0.645 3.949 ± 0.879 0.332 ± 0.085 0.278 ± 0.068 AUC0 → ∞ µg h mL-1 5.236 ± 0.194 4.616 ± 1.138 0.428 ± 0.083 0.424 ± 0.129 AUMC µg h2 mL-1 62.033 ± 27.480 58.035 ± 22.078 7.354 ± 2.834 8.598 ± 3.927 MRT h 11.522 ± 3.506 13.275 ± 4.365 17.098 ± 5.697 19.623 ± 4.283 t1/2,z h 7.909 ± 3.305 8.939 ± 2.343 10.891 ± 4.169 14.303 ± 3.761 Vd/F L Kg-1 5.545 ± 1.440 7.465 ± 2.722     CLS/F L Kg-1 h-1 0.491 ± 0.088 0.569 ± 0.126     Cmax: Maximum concentration in pigs plasma; Tmax: Time when maximum concentration was obtained. AUC0→t: Area under the concentration-time curve from the time zero to t; AUC0→∞: Area under the concentration-time curve from the time zero to infinity in pigs plasma; AUMC: Area under the first moment concentration-time curve; MRT: Mean residue time of drug in body; λZ : Terminal slope of the drug concentration-time curve; t1/2,z: Half-life of the drug; CLs/F: Total body clearance; Vd/F: Apparent volume of distribution.

Table 4: Pharmacokinetic parameters that describe the disposition of Enrofloxacin and its metabolite Ciprofloxacin in pigs plasma (n=10) after multiple intramuscular injection of Enromic® 10% (2.5 mg kg-1 per day of ENR).

Goto home»