|
Cmax, ng/mL |
tmax, ha |
AUCT, ng.h/mL |
AUC, ng.h/mL |
t1/2, h |
Cl/F, L/h/kg |
Vz/F, L/kg |
Midazolam 4 mg |
Midazolam |
|
|
|
|
|
|
|
Mean (SD) |
20 (9.02) |
0.50 |
44.52 (19.78) |
45.72 (20.31) |
4.29 (1.63) |
1.31 (0.54) |
7.54 (3.54) |
%CV |
45 |
|
44 |
44 |
38 |
41 |
47 |
Geometric mean |
18.3 |
|
40.78 |
41.90 |
3.96 |
1.21 |
6.89 |
Min, Max |
7.37, 48.4 |
0.25, 1.00 |
20.50, 103.8 |
21.12, 106.6 |
1.48, 7.31 |
0.49, 2.30 |
3.92, 16.70 |
1'-Hydroxymidazolam |
|
|
|
|
|
|
|
Mean (SD) |
9.73 (4.32) |
0.50 |
18.94 (6.39) |
19.99 (6.42) |
4.72 (2.15) |
NA |
NA |
%CV |
44 |
|
34 |
32 |
45 |
NA |
NA |
Geometric mean |
8.86 |
|
17.90 |
19.02 |
4.27 |
NA |
NA |
Min, Max |
4.24, 19.50 |
0.25, 1.00 |
9.55, 32.05 |
10.28, 33.77 |
1.57, 9.05 |
NA |
NA |
Midazolam 4 mg + desvenlafaxine 400 mg |
Midazolam |
|
|
|
|
|
|
|
Mean (SD) |
16.5 (6.24) |
0.50 |
30.62 (12.81) |
31.41 (13.03) |
3.79 (1.75) |
1.89 (0.76) |
9.36 (4.85) |
%CV |
38 |
|
42 |
41 |
46 |
40 |
52 |
Geometric mean |
15.4 |
|
28.17 |
28.95 |
3.39 |
1.75 |
8.53 |
Min, Max |
6.32, 29.2 |
0.25, 1.00 |
14.20, 58.72 |
14.94, 59.76 |
1.54, 6.82 |
0.73, 3.31 |
4.55, 28.40 |
1’-Hydroxymidazolam |
|
|
|
|
|
|
|
Mean (SD) |
9.27 (3.29) |
0.50 |
16.33 (4.83) |
17.44 (5.56) |
5.51 (4.30) |
NA |
NA |
%CV |
35 |
|
30 |
32 |
78 |
NA |
NA |
Geometric mean |
8.72 |
|
15.69 |
16.59 |
4.39 |
NA |
NA |
Min, Max |
4.65, 16.7 |
0.25, 1.00 |
9.54, 27.69 |
10.01, 26.23 |
1.88, 15.43 |
NA |
NA |
aMedian data are presented for tmax |
