Animal_ID Cmax Tmax HL_Lambda_z AUClast AUC INF_obs Cl_F_obs Vz_Fobs AUC INF_pred AUC_%Extrap_pred MRT last (ug/mL) (hr) (hr) (hr*ug/mL) (hr*ug/m) (mL/hr/kg) (mL/kg) (hr*ug/mL) (%) (hr) Marketed Product A 16.68 2 3 87.05 87.44 74.33 321.28 87.38 0.37 4.21   B 14.01 1 3.98 93.1 94.94 68.47 393.57 95 2 6.38   C 17.78 1 4.78 96.7 100.42 64.73 446.54 99.72 3.03 5.69   D 18.69 1 3.69 109.51 123.79 52.51 279.74 123.62 11.41 4.28   E 14.54 1 2.66 67.79 71.89 90.41 346.48 71.83 5.63 3.97   F 14.57 2 3.8 104.14 105.51 61.6 337.76 105.63 1.41 5.95   N 6 6 6 6 6 6 6 6 6 6   NObs 6 6 6 6 6 6 6 6 6 6   Mean 15.09 1.333 3.652 93.05 97.334 68.675 354.23 97.197 3.975 5.079   SD 1.87 0.50 0.753 14.706 7.478 12.897 58.369 17.437 4.06 1.02   Min 14.01 1 2.66 67.79 71.89 52.51 279.74 71.83 0.37 3.97   Median 15.63 1 3.75 94.9 97.68 66.6 342.12 97.36 2.51 4.98   CV% 12.1 38.7 20.6 15.8 18 18.8 16.5 17.9 102.1 20.5 Spherical aggl. Dense compacts (Our form) A 19.02 1 3.76 107.25 108.07 60.15 326.46 108.03 0.72 4.3   B 17.31 2 14.98 105.65 128.34 50.65 1094.65 128.77 17.96 6   C 22.19 1 3.59 130.58 148.43 43.79 226.69 146.67 10.97 4.2   D 21.11 1 6.18 94.65 102.94 63.14 563.12 100.72 6.03 5.92   E 15.18 1 3.66 77.29 86.68 74.99 395.84 86.74 10.9 4.08   F 16.59 1 5.76 114.04 120.27 54.04 449.2 120.35 5.25 6.79   N 6 6 6 6 6 6 6 6 6 6   NObs 6 6 6 6 6 6 6 6 6 6   Mean 18.39 1.167 6.322 104.907 115.789 57.793 509.325 115.215 8.639 5.253   SD 2.59 0.51 4.392 17.98 12.9 10.872 308.324 21.315 5.973 1.162   Min 15.18 1 3.59 77.29 86.68 43.79 226.69 86.74 0.72 4.08   Median 18.17 1 4.76 106.45 114.17 57.1 422.52 114.19 8.47 5.11   CV% 14.6 35 69.5 17.1 18.6 18.8 60.5 18.5 69.1

Table 3: Pharmacokinetic parameters of Zaltoprofen Marketed product and Spherical Agglomerates (Directly compressible spherical agglomerates).

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