Post-processing stability test (ng/mL)
(n=5)
Reference values
Values after 72 h 30 min
Reference values
Values after 72 h 30 min
Reference values
Values after 72 h 30 min
Low sample
Medium sample
High sample
Arithmetic Mean
16.7
16.2
80.5
75.3
300
275
CV (%)
1.8
3.9
2.1
13.4
2.6
3.2
Variation
-3,0
-6.5
-8.3
Freeze-and-thaw stability test (ng/mL)
(n=5)
Reference values
Values after 3 cycles
Reference values
Values after 3 cycles
Reference values
Values after
3 cycles
Low sample
Medium sample
High sample
Arithmetic Mean
13.1
11.8
57.6
52.2
196
185
CV (%)
4.8
6.2
3.1
4.0
8.9
1.5
Variation
-9.9
-9.4
-5.6
Short-term stability test (ng/mL)
(n=5)
Reference values
Values after 8 h 30 min
Reference values
Values after 8 h 30 min
Reference values
Values after 8 h 30 min
Low sample
Medium sample
High sample
Arithmetic Mean
13.1
11.7
57.6
50.5
196
170
CV (%)
4.8
5.1
3.1
5.3
8.9
3.7
Variation
-10.7
-12.3
-13.3
Table 2:
Stability quality control plasma samples (15.0, 80.0 and 320.0 ng/mL for hydroxocobalamin) to short-term (8 h 30 min) room temperature, three freeze/thaw (-20 to 25°C) cycles and 72 h 30 min auto-sampler stability (6°C).
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