| Pharmacokinetic Parameters of |
|
REFERENCE |
|
|
TEST |
|
|
| Armodafinil |
Mean |
S.D. |
S.E. |
% CV |
Mean |
S.D. |
S.E. |
% CV |
| Cmax (ng/ml) |
6959.753 |
2559.8374 |
502.0254 |
36.78 |
6488.820 |
1004.7503 |
197.0477 |
15.48 |
| AUC(0-t) (ng/ml*hr.) |
143561.459 |
52789.8707 |
10352.9454 |
36.77 |
137472.353 |
32290.6130 |
6332.7102 |
23.49 |
| AUC(0-∞) (ng/ml*hr.) |
147026.136 |
55298.4989 |
10844.9279 |
37.61 |
140994.394 |
33934.4906 |
6655.1012 |
24.07 |
| -1 Cmax / AUC(0-∞) (hr) |
0.0491 |
0.0106 |
0.0021 |
21.63 |
0.0480 |
0.0107 |
0.0021 |
22.27 |
| Tmax (hr) |
1.875 |
0.9145 |
0.1793 |
48.77 |
2.288 |
1.2363 |
0.2425 |
54.02 |
| Kel (hr) |
0.048 |
0.0167 |
0.0033 |
34.38 |
0.044 |
0.0127 |
0.0025 |
28.90 |
| T1/2 (hr) |
15.608 |
4.5168 |
0.8858 |
28.94 |
16.613 |
4.3864 |
0.8602 |
26.40 |
| ln Cmax (ng/ml) |
8.8095 |
0.2507 |
0.0492 |
2.85 |
8.7663 |
0.1552 |
0.0304 |
1.77 |
| ln AUC(0-t) (ng/ml*hr.) |
11.8217 |
0.3250 |
0.0637 |
2.75 |
11.7992 |
0.2718 |
0.0533 |
2.30 |
| ln AUC(0-∞) (ng/ml*hr.) |
11.8441 |
0.3277 |
0.0643 |
2.77 |
11.8234 |
0.2756 |
0.0540 |
2.33 |
| ln (Cmax / AUC(0-∞))(hr-1) |
-3.0345 |
0.2001 |
0.0393 |
-6.60 |
-3.0572 |
0.2049 |
0.0402 |
-6.70 |
|
