Parameters
C
1
(1.28 mg/kg)
C
1a
(1.65 mg/kg)
C
2
(0.98 mg/kg)
C
2a
(1.10 mg/kg)
Total (5.00 mg/kg)
t
1/2
b
(h)
2.67 ± 0.76
3.39 ± 1.15
4.70 ± 0.63
6.61 ± 0.94
3.78 ± 0.35
MRT
(h)
3.45 ± 0.54
4.85 ± 0.98
5.93 ± 0.53
8.76 ± 0.90
4.43 ± 0.24
Vd
area
/F
(ml/kg)
304.30
a
± 0.57
674.52
b
± 0.74
972.63
b,c
± 0.50
1242.65
c
± 0.62
679.26
b
± 0.33
CL
B
/F
(ml/hr/kg)
79.04 ± 0.43
137.68 ± 0.90
144.46 ± 0.40
130.32 ± 0.68
124.59 ± 0.37
AUC
0-∞
/Dose
(mg.h.kg/ml/mg)
12.65 ± 0.43
7.26 ± 0.90
6.92 ± 0.40
7.68 ± 0.68
8.03 ± 0.37
Extrapolated AUC
(%)
10 ± 0.69
23 ± 0.69
22 ± 0.37
40 ± 0.35
12 ± 0.64
Bioavailability (%)
101 ± 0.65
58 ± 0.88
78 ± 0.48
64 ± 0.79
77 ± 0.42
C
max
/Dose
Median (25
th
-75
th
percentile) (µg/mL)
4.48
a
(3.81-5.82)
2.49
b
(1.59-3.05)
1.94
b
(1.51-2.37)
1.73
b
(1.25-2.05)
2.51
a.b
(2.19-2.30)
T
max
Median
(25
th
-75
th
percentile) (h)
0.50 (0.50-1.00)
0.50 (0.50-1.00)
0.50 (0.50-0.50)
0.50 (0.50-1.00)
0.50 (0.50-1.00)
Values are mean ± SE (n=10)
a,b
Different superscripts indicate statistically significant differences
Table 2:
The pharmacokinetics parameters of gentamicin C
1a
, C
2a
, C
1
, C
2
, and total gentamicin following single IM administration.
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