The pharmacokinetics parameters of gentamicin

Parameters	C₁ (1.28 mg/kg)	C_1a (1.65 mg/kg)	C₂ (0.98 mg/kg)	C_2a (1.10 mg/kg)	Total (5.00 mg/kg)
t_1/2(h)	1.54 ± 0.86^a	2.37 ± 0.65^a,b	3.32 ± 0.59^b	3.54 ± 0.45^b	2.21 ± 0.27^a,b
MRT (h)	2.35 ± 0.56^a	3.26 ± 0.48^a,b	3.81 ± 0.35^b	4.09 ± 0.32^b	2.71 ± 0.20^a,b
Vd_area/F (ml/kg)	217.89^a ± 0.77	785.25^b ± 0.50	586.99^b,c ± 0.24	603.05^b,c ± 0.35	443.63^c ± 0.40
CL_B/F (ml/hr/kg)	98.20^a ± 0.48	229.29^b ± 0.34	122.49^a ± 0.53	118.04^a ± 0.36	139.07^a ± 0.34
AUC_0-∞/Dose (mg.h.kg/ml/mg)	10.18 ± 0.48^a	4.36 ± 0.34^b	8.16 ± 0.53^a	8.47 ± 0.36^a	7.20 ± 0.34^a
Extrapolated AUC (%)	11 ± 0.84	18 ± 0.44	15 ± 0.64	18 ± 0.56	3 ± 0.39
Bioavailability (%)	81 ± 0.66^a	35 ± 0.65^b	92 ± 0.52^a	70 ± 0.43^a	69 ± 0.29^a
C_max/Dose Median (25^th-75^th percentile) (µg/mL)	4.74^a (4.01-7.06)	1.79^b (1.35-1.87)	2.81^a (1.91-3.27)	2.78^a (2.08-3.80)	2.85^a (2.70-3.62)
T_max Median (25^th-75^th percentile) (h)	0.50 (0.50-1.00)	1.00 (0.50-1.00)	0.75 (0.50-1.00)	0.50 (0.50-1.00)	0.50 (0.50-1.00)

^a,bDifferent superscripts indicate statistically significant differences

Table 3: The pharmacokinetics parameters of gentamicin C_1a, C_2a, C₁, C₂, and total gentamicin following single SC administration. Values are mean ± SE (n=10).

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