| Parameter |
Point Estimate |
90% CI |
| FF dose proportionality |
| AUC(0–t’) (pg•h/mL) |
Log (dose) |
0.910 |
(0.843, 0.978) |
| Cmax (pg/mL) |
Log (dose) |
0.484 |
(0.400, 0.569) |
| VI equivalence |
| AUC(0–t’) (pg•h/mL) |
Log (dose) |
0.029 |
(–0.018, 0.077) |
| Cmax (pg/mL) |
Log (dose) |
0.055 |
(–0.010, 0.121) |
AUC(0-t’) = area under the curve from zero (pre-dose) to the time of last common measurable time point within subject; CI = confidence interval; Cmax = maximum plasma concentration; FF = fluticasone furoate; VI = vilanterol. |
