Metabolite Rt [min] m/z Proposed Formula Major metabolites in plasma PGL4004 (didemethylated UPA) 26.39 448.25 C28H34O4N1 PGL4002 (monodemethylated UPA) 29.77 462.26 C29H36O4N1 UPA 33.41 476.28 C30H38O4N1 Minor metabolites in plasma Hydroxylated PGL4004 23.01 464.24 C28H34O5N1 PGL4004 +2H 24.31 450.26 C28H36O4N1 PGL4002 +2H 26.39 464.28 C29H38O4N1 Hydroxylated UPA 27.43 492.28 C30H38O5N1 Metabolites in faeces Hydroxylated UPA +Glutathioneconjugate 21.96 781.35 C40H53O10N4S1 UPA +2H 22.68 478.29 C30H40O4N1 AcetylatedUPA 25.83 518.29 C32H40O5N1 PGL4002 30.83 462.26 C29H36O4N1 UPA +2O ‑2H 31.01 506.25 C30H36O6N1 Hydroxylated PGL4004 --* 464.24 C28H34O5N1 * indicates that no radio-trace was available; Rt: retention time (radio-detection); m/z: mass-to-charge ratio

Table 3: Liquid chromatography/mass spectrometry identification of ulipristal acetate (UPA) metabolites.

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