| S.NO |
Time(hours) and Pharmacokinetic parameters |
Nano formulation |
Pure drug |
| Concentration (ng/mL) |
Concentration (ng/mL) |
| 1 |
0 |
0 |
0 |
| 2 |
0.5 |
10.83635 |
9.54953 |
| 3 |
1 |
22.85125 |
10.3611 |
| 4 |
2 |
31.7934 |
15.07157 |
| 5 |
3 |
83.7119 |
106.6077 |
| 6 |
5 |
198.72836 |
125.37766 |
| 7 |
7 |
236.41532 |
169.30415 |
| 8 |
8 |
219.10241 |
195.4973 |
| 9 |
10 |
159.83774 |
165.18968 |
| 10 |
12 |
130.5835 |
120.38341 |
| 11 |
18 |
124.9776 |
109.0875 |
| 12 |
24 |
114.9085 |
98.0976 |
| 13 |
Cmax |
236.41532 |
195.4973 |
| 14 |
Tmax |
7 |
7 |
| 15 |
AUC0-t |
3197.25176 |
2746.21701 |
| 16 |
keli (h-1) |
0.03953183 |
0.03829696 |
| 17 |
t½ (h) |
17.5339 |
18.0992749 |
| 18 |
AUCo-α |
9177.63037 |
7850.99052 |
|
