Formulation A B C D E ScoS(ml) 1:2 1:3 2:1 3:1 4:1 Oil % 25 30 20 15 10 S% 14.5 12.7 22 18.7 16 Cos% 29.3 38.2 11 6.25 4 Aq% 31 19 47 61 70 Globule size(nm) 90 254.3 212 40 - PDI 0.287 0.723 0.398 0.910 - Zeta Potential(mV) -19.0 -17 -22 -5 - Viscosity(cP) 22.3 30.1 19.2 - - Conductivity(μS/cm) 451.3 - 522.3 - - Refractive Index 1.49 - 1.27 - - Transmittance 99.43 - 98.9 - -

S. No. PARAMETER METHOD 1 Globule size & polydispersity index Zetasizer 3000 ( Malvern Instruments Worcestershire, UK) (Figure 6) 2 External Morphological Study Scanning Electron Microscopy (Figure 7) 3 Viscosity determination Brookfield DV-II ultra+ viscometer 4 Electro conductivity study Electro conductometer (Conductivity meter 305, Systronic). 5 Refractive index and percent transmittance Abbe refractometer & UV spectrophotometer 6 In vivo performance 50,100, 1000 times dilution with various dissolution media viz: 0.1N Hcl (pH 1.2) and biorelevant media.

Table 4: The formulated SNEDDS in vitro.

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