Table 1 concomitantly with curcumin

parameters	control	curcumin
AUC_0-60/ng·h·mL^-1	1712.1 ± 284.7	982.3 ± 188.0***
AUC_0-∞/ng·h·mL^-1	1810.2 ± 293.2	1051.0 ± 231.5***
C_max/ng·mL	138.7 ± 42.1	97.9 ± 28.7*
t_max/h	2.0 ± 0.7	1.8 ± 0.3
t_1/2/h	12.2 ± 2.2	13.3 ± 6.1
CL/F (L·h^-1)	28.3 ± 4.8	50.1 ± 12.9**

AUC_0-60: Area Under Plasma Concentration–time curve from 0 to 60 hours; AUC_0-∞: Area Under Plasma Concentration–time curve from 0 hours to infinity; C_max: Highest observed plasma concentration; t_max: Time to reach C_max; t_1/2: Elimination half-life; CL/F: Total clearance *: P<0.05; **: P<0.01; ***: P<0.001

Table 1: Pharmacokinetic parameters of talinolol in healthy volunteers administered as a single oral dose of 50 mg alone (control) or concomitantly with curcumin (means ± SD, n=12).

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