expression and relative MDR1 mRNAs levels

Groups	Con. (μmol/L)	Function¹	Expression²	MDR1 mRNA levels³
Blank control	-	648.82 ± 9.23	28.75 ± 6.25	1.04 ± 0.25
Curcumin	0.1	608.52 ± 7.52*	114.16 ± 5.52*	1.58 ± 0.10*
	0.5	504.24 ± 7.13*	126.01 ± 4.53*	1.60 ± 0.08*
	1	429.31 ± 8.30*	133.13 ± 5.58·*	1.62 ± 0.05*
Tetrahydrocurcumin	0.5	562.52 ± 6.54*	106.32 ± 5.10*	1.32 ± 0.09*
	1	486.72 ± 8.93*	117.88 ± 6.38*	1.35 ± 0.06*
	5	380.74 ± 7.85*	124.93 ± 3.87*	1.36 ± 0.04*
Rifampicin	10	195.82 ± 5.98*	148.75 ± 4.99*	1.74 ± 0.27*
Plasma samples	-	250.02 ± 10.18*^#	—	— —
CsA	5	982.28 ± 10.25·*	19.59 ± 3.11*	0.66 ± 0.07*·

¹The intracellular fluorescence of Rh-123;
²Protein expression of p-gp;
³Relative MDR1 mRNA levels of p-gp (ratio of MDR1 mRNA levels and mRNA levels of the internal reference β-actin);
*P<0.05 versus blank control group;
^#P<0.05 versus curcumin and tetrahydrocurcumin groups

Table 2: The concentration-dependent induction of p-gp function, expression and relative MDR1 mRNAs levels by curcumin and tetrahydrocurcumin. The blank control group was treated with PBS buffer (means ± SD, n=5).

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