Difference Chapter <701> Chapter <2040>
Apparatus Six cell basket rack assembly Dissolution apparatus 2
Volume of test medium 1000 mL 500 mL
Hydrodynamics Up/down strokes Rotary paddle
Duration NMT 45 minutes NMT 15 minutes
End point No palpable firm core Rupture of capsule shell
Table 1: Differences between disintegration test (USP chapter <701>) and rupture test (USP chapter <2040>).
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